Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 8/20 | 0.36 |
| ▸ | BRAF | P15056 | 7/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39854 | 0.91 | SLC34A2 (0.56) | SLC34A2MAPK1RAF1BRAFROCK2 | |
| SCHEMBL18059153 | 0.88 | SLC34A2 (0.49) | SLC34A2ROCK2MAPK14ROCK1GPR52 | |
| SCHEMBL46660 | 0.82 | SLC34A2 (0.62) | SLC34A2MAPK1RAF1BRAFROCK2 | |
| SCHEMBL18059182 | 0.80 | SLC34A2 (0.55) | SLC34A2ROCK2MAPK14ROCK1GPR52 | |
| SCHEMBL39901 | 0.79 | MAPK1 (0.56) | SLC34A2MAPK1EPHX2RAF1BRAF | |
| SCHEMBL40087 | 0.78 | SLC34A2 (0.61) | SLC34A2ROCK2MAPK14ROCK1GPR52 | |
| SCHEMBL40143 | 0.78 | SLC34A2 (0.61) | SLC34A2ROCK2MAPK14ROCK1MLYCD | |
| SCHEMBL40151 | 0.78 | MAPK1 (0.49) | SLC34A2MAPK1EPHX2RAF1BRAF | |
| SCHEMBL39717 | 0.77 | SLC34A2 (0.57) | SLC34A2RAF1BRAF | |
| SCHEMBL18482323 | 0.77 | SLC34A2 (0.53) | SLC34A2MAPK1EPHX2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |