Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46470 | 0.85 | CLK4 (0.48) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL18059156 | 0.79 | CLK4 (0.46) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL39097 | 0.79 | CLK4 (0.58) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL40589 | 0.77 | ROCK2 (0.46) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL46461 | 0.76 | SLC34A2 (0.54) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL6001515 | 0.73 | SLC34A2 (0.42) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL46471 | 0.73 | SLC34A2 (0.46) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL15432596 | 0.72 | CYP1A2 (0.55) | CLK4CDC7ROCK2PIM1PRKACA | |
| SCHEMBL46732 | 0.71 | CDC7 (0.41) | CLK4CDC7ROCK2MAP4K4PIM1 | |
| SCHEMBL16298245 | 0.70 | MRGPRX4 (0.66) | MRGPRX4MEN1KMT2ANR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |