Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 2/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19466139 | 1.00 | KDM1A (0.39) | KDM1ATP53THRBKMT2AALOX15 | |
| SCHEMBL18059507 | 0.92 | KDM1A (0.46) | KDM1AKMT2A | |
| SCHEMBL18848608 | 0.92 | KDM1A (0.46) | KDM1AKMT2A | |
| SCHEMBL18059520 | 0.89 | KDM1A (0.49) | KDM1AKMT2AALOX15HTTSMN1; SMN2 | |
| SCHEMBL18848473 | 0.89 | KDM1A (0.49) | KDM1AKMT2AALOX15HTTSMN1; SMN2 | |
| SCHEMBL18848438 | 0.88 | KDM1A (0.44) | KDM1AKMT2AALOX15HTTSMN1; SMN2 | |
| SCHEMBL18059490 | 0.88 | KDM1A (0.44) | KDM1AKMT2AALOX15HTTSMN1; SMN2 | |
| SCHEMBL18848753 | 0.80 | KDM1A (0.52) | KDM1A | |
| SCHEMBL18059481 | 0.80 | KDM1A (0.52) | KDM1A | |
| SCHEMBL18848713 | 0.79 | UGCG (0.35) | KDM1AKMT2AMTTPMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10882835-B2 | KDM1A inhibitors for the treatment of disease | IMAGO BIOSCIENCES, INC. (US) | 2021-01-05 | — | — | US | disclosed |
| US-20170334873-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. | 2017-11-23 | — | — | US | disclosed |
| US-9790195-B2 | KDM1A inhibitors for the treatment of disease | IMAGO BIOSCIENCES, INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160257662-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | IMAGO BIOSCIENCES, INC. | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334873-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | KDM1B, KDM1A, KDM2A | KDM1A 2/4885TP53 524/4885THRB 2389/4885 |
| US-10882835-B2 | KDM1A inhibitors for the treatment of disease | KDM1B, KDM1A, KDM2A | KDM1A 2/4885TP53 524/4885THRB 2389/4885 |
| US-20160257662-A1 | KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE | KDM1B, KDM1A, KDM2A | KDM1A 2/4885TP53 601/4885THRB 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.