Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL1805960

O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.c1cc(-c2ccc(N3CC4CNCC4C3)nn2)co1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.74
KCNH2 Q12809 1/20 0.44
CHRNA4 P43681 4/20 0.43
CHRNB2 P17787 3/20 0.41
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
HTR3A P46098 1/20 0.40
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL928155 0.89 CHRNA7 (0.67) CHRNA7KCNH2CHRNA4CHRNB2CHRNB4
Trifluoroacetic Acid SCHEMBL1791576 0.85 CHRNA7 (1.00) CHRNA7KCNH2CHRNA4CHRNB2CHRNB4
Trifluoroacetic Acid SCHEMBL927721 0.84 CHRNA7 (0.83) CHRNA7KCNH2CHRNA4CHRNB2CHRNB4
Trifluoroacetic Acid SCHEMBL1791261 0.83 CHRNA7 (0.81) CHRNA7KCNH2CHRNB4CHRNA3HTR3A
Trifluoroacetic Acid SCHEMBL1793074 0.82 CHRNA4 (0.58) CHRNA7CHRNA4CHRNB2CHRNB4CHRNA3
Trifluoroacetic Acid SCHEMBL1792510 0.82 CHRNA7 (0.76) CHRNA7KCNH2CHRNA4CHRNB2CHRNB4
Trifluoroacetic Acid SCHEMBL6324918 0.79 CHRNA7 (0.78) CHRNA7KCNH2CHRNB4CHRNA3HTR3A
Trifluoroacetic Acid SCHEMBL1792771 0.79 CHRNA7 (0.78) CHRNA7KCNH2CHRNB4CHRNA3HTR3A
Trifluoroacetic Acid SCHEMBL1792562 0.78 CHRNA7 (0.74) CHRNA7KCNH2CHRNB4CHRNA3HTR3A
SCHEMBL2328660 0.77 CHRNA7 (0.50) CHRNA7KCNH2CHRNA4CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2316836-A1 Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors Abbott Laboratories (US) 2011-05-04 EP disclosed