Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928155 | 0.87 | CHRNA7 (0.67) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| SCHEMBL2331059 | 0.85 | CHRNA7 (0.50) | CHRNA7HTR3ACHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL2322822 | 0.83 | CHRNA7 (0.72) | CHRNA7HTR3ACHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL2361063 | 0.78 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL1805960 | 0.77 | CHRNA7 (0.74) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 | |
| SCHEMBL930385 | 0.76 | CHRNA7 (0.67) | CHRNA7HTR3ACHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL3391442 | 0.75 | CHRNA7 (0.45) | CHRNA7HTR3ACHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL2329587 | 0.74 | KMT2A (0.60) | CHRNA7CHRNB4CHRNA3CYP1A2CHRNA4 | |
| SCHEMBL2677896 | 0.73 | CHRNA7 (0.43) | CHRNA7HTR3ACHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL927977 | 0.67 | CHRNA7 (1.00) | CHRNA7HTR3ACHRNB4CHRNA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257168-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2011-10-20 | — | — | US | claimed |
| US-20110257168-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2011-10-20 | — | — | US | disclosed |
| EP-2356125-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | Targacept, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010002971-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257168-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA5, CHRNA2, CHRNB2 | CHRNA7 5/4885HTR3A 351/4885CHRNB4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.