Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL3 | P15374 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | BLK | P51451 | 3/20 | 0.46 |
| ▸ | BMX | P51813 | 2/20 | 0.46 |
| ▸ | CTSC | P53634 | 11/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.46 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.46 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18060720 | 0.83 | UCHL3 (0.51) | UCHL3ERBB2EGFRJAK3JAK2 | |
| SCHEMBL12806084 | 0.83 | UCHL3 (0.51) | UCHL3ERBB2EGFRJAK3JAK2 | |
| SCHEMBL18060908 | 0.80 | CTSC (0.48) | UCHL3ERBB2EGFRJAK3JAK2 | |
| SCHEMBL18060691 | 0.78 | CTSC (0.55) | EGFRJAK3JAK2BLKBMX | |
| SCHEMBL18060652 | 0.77 | EHMT2 (0.44) | EGFRJAK3BTKITKGAK | |
| SCHEMBL18060638 | 0.75 | JAK3 (0.45) | UCHL3ERBB2EGFRJAK3JAK2 | |
| SCHEMBL18060636 | 0.75 | JAK3 (0.45) | UCHL3ERBB2EGFRJAK3JAK2 | |
| SCHEMBL12805653 | 0.75 | EHMT2 (0.44) | EGFRBTKFLT3ITK | |
| SCHEMBL12806017 | 0.74 | JAK3 (0.45) | ERBB2EGFRJAK3JAK2BLK | |
| SCHEMBL1275419 | 0.74 | JAK3 (0.48) | ERBB2EGFRJAK3JAK2BLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205647-B1 | 2-(PYRIMIDIN-5-YL)-THIOPYRIMIDINE DERIVATIVES AS HSP70 AND HSC70 MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2020-05-13 | — | — | EP | disclosed |
| EP-3205647-A2 | 2-(PYRIMIDIN-5-YL)-THIOPYRIMIDINE DERIVATIVES AS HSP70 AND HSC70 MODULATORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Memorial Sloan-Kettering Cancer Center (US) | 2017-08-16 | — | — | EP | disclosed |
| EP-2467142-B1 | 2-(Pyrimidin-5-yl)-thiopyrimidine derivatives as Hsp70 and Hsc70 modulators for the treatment of proliferative disorders | SLOAN KETTERING INST CANCER (US) | 2016-09-21 | — | — | EP | disclosed |