SCHEMBL1806342

SCHEMBL1806342

CNc1cccc(C(=O)O)c1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.48
POLB P06746 1/20 0.48
ATM Q13315 1/20 0.48
ALB P02768 1/20 0.47
FABP4 P15090 4/20 0.47
FABP3 P05413 1/20 0.46
FABP5 Q01469 1/20 0.46
KMT2A Q03164 5/20 0.46
MEN1 O00255 4/20 0.46
LMNA P02545 2/20 0.46
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 2/20 0.46
PTGS2 P35354 2/20 0.46
AKR1C3 P42330 2/20 0.46
HIF1A Q16665 2/20 0.46
AKR1B10 O60218 1/20 0.46
TRPA1 O75762 1/20 0.46
ABCB11 O95342 1/20 0.46
DHFR P00374 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11246515 0.85 KMT2A (0.53) KDM4EPOLBATMKMT2AMEN1
SCHEMBL28282536 0.85 KDM4E (0.46) KDM4EPOLBATMLMNAALDH1A1
SCHEMBL14087848 0.84 FABP4 (0.47) KDM4EALBFABP4FABP3FABP5
SCHEMBL1803598 0.83 KDM4E (0.68) KDM4EPOLBATMKMT2ALMNA
SCHEMBL5391081 0.82 FABP4 (0.49) KDM4EPOLBALBFABP4KMT2A
SCHEMBL22797015 0.82 POLB (0.43) KDM4EPOLBATMKMT2AMEN1
SCHEMBL22152375 0.82 KDM4E (0.43) KDM4EPOLBATMFABP4KMT2A
SCHEMBL5499369 0.81 HPGD (0.54) KDM4EKMT2AMEN1LMNACYP1A2
N-Methylanthranilic Acid SCHEMBL29381752 0.81 KDM4E (0.64) KDM4EPOLBATMFABP4FABP3
N-Methylanthranilic Acid SCHEMBL130356 0.81 KDM4E (0.64) KDM4EPOLBATMFABP4FABP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805102-A Bisamide derivative intermediate and process for producing bisamide derivative 上海陶术生物科技有限公司 2022-07-29 CN disclosed
EP-2322502-B1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2019-09-18 EP disclosed
WO-2019053426-A1 FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA ATROGI AB (SE) 2019-03-21 WO disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2016-10-13 US disclosed
US-9394240-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-07-19 US disclosed
US-8853440-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2014-10-07 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
CN-102119144-A Method for producing amide derivative MITSUI CHEMICALS AGRO INC 2011-07-06 CN disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
EP-2322502-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2011-05-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 KDM4E 1089/4885POLB 4756/4885ATM 1835/4885
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 KDM4E 1089/4885POLB 4756/4885ATM 1835/4885
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 KDM4E 1089/4885POLB 4756/4885ATM 1835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.