Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3110902 | 0.86 | GRM4 (0.61) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL18071015 | 0.84 | GRM4 (0.48) | GRM4KDR | |
| SCHEMBL3118050 | 0.81 | GRM4 (0.70) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL18049838 | 0.81 | KDR (0.52) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29377800 | 0.81 | GRM4 (0.55) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL17643720 | 0.81 | GRM4 (0.55) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3122821 | 0.81 | TMPRSS4 (0.61) | GRM4KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL18049791 | 0.78 | KDR (0.61) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL16616963 | 0.77 | MEN1 (0.61) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7277038 | 0.77 | ATM (0.67) | GRM4KMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |