Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 6/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18070887 | 0.84 | GRM4 (0.52) | GRM4KDR | |
| SCHEMBL18048984 | 0.78 | KDR (0.45) | GRM4KDRAR | |
| SCHEMBL18070904 | 0.76 | LRRK2 (0.36) | GRM4LRRK2KDRAR | |
| SCHEMBL18070905 | 0.76 | LRRK2 (0.36) | GRM4LRRK2KDRAR | |
| SCHEMBL18048923 | 0.76 | LRRK2 (0.36) | GRM4LRRK2KDRAR | |
| SCHEMBL18070920 | 0.76 | MAPT (0.61) | KCNQ3KCNQ2KCNE1KCNQ1TMPRSS4 | |
| SCHEMBL31448688 | 0.74 | AR (0.56) | SLC22A12AR | |
| SCHEMBL27359796 | 0.74 | AR (0.56) | SLC22A12AR | |
| SCHEMBL18070880 | 0.73 | KCNQ3 (0.48) | KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL18070914 | 0.71 | MAPK1 (0.56) | KDRKCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |