Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.77 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | LSS | P48449 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048949 | 0.88 | KDR (0.84) | KDRPDPK1FLT1ABCB1MEN1 | |
| SCHEMBL18049824 | 0.88 | KDR (0.84) | KDRPDPK1FLT1ABCB1 | |
| SCHEMBL15528901 | 0.87 | KDR (0.87) | KDRABCB1MEN1ALDH1A1LMNA | |
| SCHEMBL427743 | 0.87 | KDR (1.00) | KDRFLT1ABCB1 | |
| SCHEMBL18049837 | 0.86 | KDR (0.77) | KDRPDPK1FLT1MEN1ALDH1A1 | |
| SCHEMBL6103635 | 0.83 | KDR (0.80) | KDRPDPK1FLT1MEN1ALDH1A1 | |
| SCHEMBL18070995 | 0.81 | KDR (0.62) | KDRPDPK1FLT1MEN1ALDH1A1 | |
| SCHEMBL18073539 | 0.81 | KDR (0.76) | KDRPDPK1MEN1ALDH1A1LMNA | |
| SCHEMBL426512 | 0.81 | KDR (0.86) | KDRFLT1ABCB1 | |
| SCHEMBL6104460 | 0.81 | KDR (0.69) | KDRPDPK1FLT1ABCB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |