Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049817 | 0.90 | KDR (0.62) | KDRPDPK1KDM4EGAAMEN1 | |
| SCHEMBL18071008 | 0.87 | KDR (0.51) | KDRFLT1 | |
| Hydrochloric Acid SCHEMBL18049782 | 0.86 | KDR (0.50) | KDRFLT1 | |
| SCHEMBL18071007 | 0.85 | KDR (0.55) | KDRPDPK1KDM4EGAAMEN1 | |
| SCHEMBL18071021 | 0.84 | KDR (0.61) | KDRPDPK1KDM4EGAAMEN1 | |
| SCHEMBL3107865 | 0.83 | KDR (0.83) | KDRFLT1CITMAP3K7RIPK2 | |
| SCHEMBL18049791 | 0.83 | KDR (0.61) | KDRPDPK1KDM4EGAAMEN1 | |
| SCHEMBL18049814 | 0.83 | KDR (0.63) | KDRPDPK1KDM4EGAAMEN1 | |
| SCHEMBL18070970 | 0.81 | KDR (0.77) | KDRPDPK1MEN1MAPTKMT2A | |
| SCHEMBL6103207 | 0.81 | PDPK1 (0.52) | KDRPDPK1KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |