Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.58 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.52 |
| ▸ | SORD | Q00796 | 7/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22519578 | 0.83 | HRH3 (0.53) | HRH3HRH4 | |
| SCHEMBL29605777 | 0.83 | HRH3 (0.53) | HRH3HRH4 | |
| SCHEMBL30954035 | 0.81 | HRH3 (0.66) | HRH3HRH4NUDT1SORDROCK2 | |
| SCHEMBL27454974 | 0.81 | HRH3 (0.66) | HRH3HRH4NUDT1SORDROCK2 | |
| SCHEMBL13018701 | 0.80 | HRH3 (0.65) | HRH3HRH4NUDT1SORDROCK2 | |
| SCHEMBL14880196 | 0.78 | HRH3 (0.71) | HRH3HRH4NUDT1SORDROCK1 | |
| SCHEMBL17626748 | 0.78 | HRH3 (0.71) | HRH3HRH4SORDROCK1OGA | |
| SCHEMBL2166795 | 0.77 | HRH3 (1.00) | HRH3HRH4ROCK2ROCK1OGA | |
| SCHEMBL20445925 | 0.77 | HRH3 (0.65) | HRH3HRH4SORDROCK2ROCK1 | |
| Bromide SCHEMBL20445910 | 0.76 | HRH3 (0.69) | HRH3HRH4NUDT1SORDROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016145383-A1 | MTH1 INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-15 | — | — | WO | disclosed |