⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644835 | 0.82 | SIGMAR1 (0.34) | — | |
| SCHEMBL8527545 | 0.80 | SIGMAR1 (0.38) | — | |
| SCHEMBL15830056 | 0.77 | MEN1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL22771800 | 0.75 | MEN1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL22771802 | 0.75 | MEN1 (0.32) | — | |
| SCHEMBL12330255 | 0.73 | — | — | |
| SCHEMBL7542444 | 0.73 | — | — | |
| SCHEMBL571158 | 0.73 | — | — | |
| SCHEMBL445535 | 0.73 | — | — | |
| SCHEMBL6648419 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393614-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2021-12-23 | — | — | US | claimed |
| WO-2020081678-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | DUKE UNIVERSITY (US) | 2020-04-23 | — | — | WO | claimed |
| CN-106632837-A | Minoxidil molecularly imprinted polymer, preparation method of minoxidil molecularly imprinted polymer, minoxidil solid-phase extraction column and method for separating and purifying minoxidil | 新疆维吾尔自治区分析测试研究院 | 2017-05-10 | — | — | CN | claimed |
| EP-2493863-B1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-02-25 | — | — | EP | claimed |
| US-8895573-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-11-25 | — | — | US | claimed |
| US-20140066422-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-03-06 | — | — | US | claimed |
| US-8394809-B2 | Phenoxy-substituted pyrimidines as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-03-12 | — | — | US | claimed |
| EP-2493863-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | claimed |
| WO-2011053701-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | claimed |
| US-20110105455-A1 | PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-05-05 | — | — | US | claimed |
| US-20060074105-A1 | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 | SERENEX, INC. (US) | 2006-04-06 | — | — | US | claimed |
| US-20210393614-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2021-12-23 | — | — | US | disclosed |
| WO-2020081678-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | DUKE UNIVERSITY (US) | 2020-04-23 | — | — | WO | disclosed |
| CN-106632837-A | Minoxidil molecularly imprinted polymer, preparation method of minoxidil molecularly imprinted polymer, minoxidil solid-phase extraction column and method for separating and purifying minoxidil | 新疆维吾尔自治区分析测试研究院 | 2017-05-10 | — | — | CN | disclosed |
| CN-105263906-A | Inhibitors of histone demethylases | EPITHERAPEUTICS APS | 2016-01-20 | — | — | CN | disclosed |
| EP-1201649-A1 | Glucocorticoid receptor modulators | Pfizer Products Inc. (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-0818439-B1 | Imide derivatives | NISSHIN FLOUR MILLING CO (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5849557-A | Oxidized phospholipid degrading enzyme and gene thereof | SUNTORY LIMITED (JP) | 1998-12-15 | — | — | US | disclosed |
| US-5847123-A | Imide derivatives for inhibiting the production of interleukin-1β and the production of tumor necrosis factor α | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0818439-A2 | Imide derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-01-14 | — | — | EP | disclosed |