Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 11/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | PRNP | P04156 | 3/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.59 |
| ▸ | DHODH | Q02127 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18089073 | 0.85 | RXFP1 (0.65) | PTGFRMEN1KMT2APRNPRXFP1 | |
| SCHEMBL4874592 | 0.84 | PDE10A (0.65) | KMT2ADHODHALDH1A1KDM4EHPGD | |
| SCHEMBL18089186 | 0.82 | RXFP1 (0.76) | PTGFRMEN1KMT2APRNPRXFP1 | |
| SCHEMBL18075857 | 0.82 | PTGFR (0.54) | PTGFRMEN1KMT2APRNPRXFP1 | |
| SCHEMBL18089172 | 0.81 | RXFP1 (0.74) | PTGFRMEN1KMT2APRNPRXFP1 | |
| SCHEMBL18075794 | 0.80 | PTGFR (0.84) | PTGFRPTGER2 | |
| SCHEMBL14553160 | 0.80 | DHODH (0.73) | PTGFRPRNPRXFP1PPARGNCOR2 | |
| SCHEMBL18089188 | 0.80 | PTGFR (1.00) | PTGFR | |
| Hydrochloric Acid SCHEMBL28389865 | 0.79 | DHODH (0.71) | PTGFRPRNPRXFP1PPARGNCOR2 | |
| SCHEMBL18089108 | 0.79 | RXFP1 (0.71) | PTGFRMEN1KMT2APRNPRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10117864-B2 | Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-11-06 | — | — | US | disclosed |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-02-08 | — | — | US | disclosed |
| EP-3271334-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016146602-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10117864-B2 | Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof | AADAC, BRD4, GOT2 | PTGFR 1602/4885MEN1 4542/4885KMT2A 1768/4885 |
| US-20180036300-A1 | SUBSTITUTED N-BICYCLO-2-ARYL-QUINOLIN-4-CARBOXAMIDES AND USE THEREOF | AADAC, BRD4, GOT2 | PTGFR 1602/4885MEN1 4542/4885KMT2A 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.