Hydrocortisone

Hydrocortisone

SCHEMBL1807734

CCC(=O)O.CCC(=O)O.CCCC(=O)O.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 known ✓ P04150 3/20 0.83
HIF1A Q16665 11/20 0.83
NR3C2 P08235 5/20 0.83
SMN1; SMN2 Q16637 4/20 0.83
HSD17B10 Q99714 3/20 0.83
PGR P06401 3/20 0.83
SERPINA6 P08185 3/20 0.83
KMT2A Q03164 3/20 0.83
CYP3A4 P08684 3/20 0.83
CYP2C19 P33261 2/20 0.83
MAPT P10636 2/20 0.83
NFKB1 P19838 2/20 0.83
SHBG P04278 2/20 0.83
LMNA P02545 3/20 0.67
AR P10275 1/20 0.67
CHRM1 P11229 1/20 0.67
POLB P06746 1/20 0.66
GAA P10253 1/20 0.66
PMP22 Q01453 2/20 0.63
TSHR P16473 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone SCHEMBL122188 1.00 HIF1A (0.83) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL4697 0.98 HIF1A (0.86) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL28908729 0.98 HIF1A (0.86) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL27961626 0.97 HIF1A (0.85) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL27804799 0.97 HIF1A (0.83) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL28435897 0.96 HIF1A (0.82) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL29263567 0.96 HIF1A (0.82) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL4278629 0.96 HIF1A (0.91) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL180227 0.96 HIF1A (0.91) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10
Hydrocortisone SCHEMBL26659908 0.95 HIF1A (0.89) HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9314357-B2 Stent for placement in living body and stent delivery system TERUMO KABUSHIKI KAISHA (JP) 2016-04-19 US disclosed
EP-2444033-B1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO CORP (JP) 2015-01-28 EP disclosed
US-8518102-B2 Stent for placement in living body, and stent delivery system TERUMO KABUSHIKI KAISHA (JP) 2013-08-27 US disclosed
EP-2322121-B1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO CORP (JP) 2013-05-29 EP disclosed
US-20120158119-A1 STENT FOR PLACEMENT IN LIVING BODY AND STENT DELIVERY SYSTEM TERUMO KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed
EP-2444033-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM Terumo Kabushiki Kaisha (JP) 2012-04-25 EP disclosed
US-20110196475-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO KABUSHIKI KAISHA (JP) 2011-08-11 US disclosed
EP-2322121-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM Terumo Kabushiki Kaisha (JP) 2011-05-18 EP disclosed