Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.86 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.86 |
| ▸ | PGR | P06401 | 3/20 | 0.86 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.86 |
| ▸ | MAPT | P10636 | 2/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.86 |
| ▸ | SHBG | P04278 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | AR | P10275 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL28908729 | 1.00 | HIF1A (0.86) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL27961626 | 0.99 | HIF1A (0.85) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL27804799 | 0.98 | HIF1A (0.83) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL122188 | 0.98 | HIF1A (0.83) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL1807734 | 0.98 | HIF1A (0.83) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL28435897 | 0.97 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL80605 | 0.96 | HIF1A (0.85) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7665 | 0.96 | HIF1A (0.91) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL221483 | 0.96 | HIF1A (0.91) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL3105442 | 0.95 | HIF1A (0.89) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10427 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4744657-A1 | THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF | National University Corporation Okayama University (JP) | 2026-05-20 | — | — | EP | claimed |
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-20250319104-A1 | MOISTURIZING CREAM FOR RADIATION DERMATITIS | PERRY ARTHUR W (US) | 2025-10-16 | — | — | US | claimed |
| US-12421281-B2 | Cyclosporine compositions and methods of use | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-09-23 | — | — | US | claimed |
| US-20250288585-A1 | SYNERGISTIC COMPOSITIONS FOR ENHANCED HAIR GROWTH AND METHODS FOR TREATING HAIR LOSS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| CN-120189477-A | Application of rhizoma polygonati and pharmaceutical composition thereof in preparation of medicines for preventing and treating kidney and liver injury | 广东省科学院生物与医学工程研究所 | 2025-06-24 | — | — | CN | claimed |
| US-20250179121-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-06-05 | — | — | US | claimed |
| US-5061700-A | SOLVENTS FOR CORTICOSTEROIDS | Dow, Gordon Jay (US) | 1991-10-29 | — | — | US | claimed |
| WO-1991007974-A1 | TOPICAL THERAPEUTIC PREPARATION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-13 | — | — | WO | claimed |
| WO-1991007169-A1 | GLYCERYL ACETATE OINTMENT VEHICLES | DOW GORDON JAY (US) | 1991-05-30 | — | — | WO | claimed |
| US-4844902-A | Topically applicable formulations of gyrase inhibitors in combination with corticosteroids | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-04 | — | — | US | claimed |
| US-4797402-A | CORTICOSTEROIDS, PEPPERMINT, UREA | DORSEY KENNETH E (US) | 1989-01-10 | — | — | US | claimed |
| EP-0241134-A1 | Pharmaceutical mixture comprising nedocromil or a salt thereof in combination with a bronchodilator | FISONS plc (GB) | 1987-10-14 | — | — | EP | claimed |
| EP-0068553-B1 | TOPICAL ANTIMICROBIAL ANTI-INFLAMMATORY COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1985-11-21 | — | — | EP | claimed |
| EP-0068553-A1 | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| US-4137311-A | CORTICOSTEROIDS, METAL ADDUCTS OF BIS(2-PYRIDYL-1-OXIDE)-DISULFIDE; DERMATITIS, ANTIINFLAMMATORY | WILLIAM H. RORER, INC. (US) | 1979-01-30 | — | — | US | claimed |