Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 6/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 14/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.57 |
| ▸ | JUN | P05412 | 13/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.57 |
| ▸ | CDK2 | P24941 | 13/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.55 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18078655 | 0.90 | MAPK8 (0.70) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL16655011 | 0.86 | CDK2 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL16654836 | 0.86 | CDK2 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL16654839 | 0.86 | CDK2 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL20764176 | 0.86 | MAPK8 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL20041398 | 0.84 | CDK2 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL21561673 | 0.84 | CDK2 (0.73) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL18078657 | 0.83 | CDK7 (0.65) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL18074096 | 0.82 | CDK7 (0.70) | CDK7MAPK8MAPK9JUNMAPK10 | |
| SCHEMBL18047414 | 0.82 | CDK7 (0.70) | CDK7MAPK8MAPK9JUNMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197392-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | THE BRIGHAM & WOMEN'S HOSPITAL, INC. (US) | 2020-06-25 | — | — | US | disclosed |
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2019-09-26 | — | — | US | disclosed |
| WO-2019035866-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | THE BRIGHAM & WOMEN'S HOSPITAL, INC. (US) | 2019-02-21 | — | — | WO | disclosed |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CDK7, CDK3, CDK17 | CDK7 1/4885MAPK8 352/4885MAPK9 506/4885 |
| US-20200197392-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | CDK7, CDK17, MTOR | CDK7 1/4885MAPK8 588/4885MAPK9 1013/4885 |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | CDK7, CDK6, CDK3 | CDK7 1/4885MAPK8 532/4885MAPK9 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.