Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.73 |
| ▸ | JUN | P05412 | 9/20 | 0.73 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.73 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.73 |
| ▸ | CDK7 | P50613 | 10/20 | 0.70 |
| ▸ | CCNK | O75909 | 8/20 | 0.70 |
| ▸ | CDK9 | P50750 | 8/20 | 0.70 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.70 |
| ▸ | CCNH | P51946 | 7/20 | 0.70 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.70 |
| ▸ | CDK13 | Q14004 | 6/20 | 0.70 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.70 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.70 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20041398 | 1.00 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16654836 | 0.96 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16655011 | 0.96 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL16654839 | 0.96 | CDK2 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL18313056 | 0.92 | CDK2 (0.75) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL18078655 | 0.92 | MAPK8 (0.70) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL20764176 | 0.91 | MAPK8 (0.73) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL20190370 | 0.91 | CDK2 (0.76) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL20190366 | 0.91 | CDK2 (0.76) | CDK2JUNMAPK8MAPK9MAPK10 | |
| SCHEMBL21234360 | 0.89 | CDK2 (0.69) | CDK2JUNMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2021-03-11 | — | — | US | disclosed |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | CDK2 837/4885JUN 4082/4885MAPK8 3032/4885 |
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | CDK2 837/4885JUN 4082/4885MAPK8 3032/4885 |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | CDK2 837/4885JUN 4082/4885MAPK8 3032/4885 |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | CDK2 837/4885JUN 4082/4885MAPK8 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.