Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 11/20 | 0.44 |
| ▸ | ARG2 | P78540 | 10/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10006313 | 0.92 | ARG1 (0.54) | ARG1ARG2DRD2DRD4DRD3 | |
| SCHEMBL29657443 | 0.92 | ARG1 (0.54) | ARG1ARG2DRD2DRD4DRD3 | |
| SCHEMBL10006101 | 0.90 | ARG1 (0.54) | ARG1ARG2DRD2DRD4DRD3 | |
| SCHEMBL29657574 | 0.90 | ARG1 (0.54) | ARG1ARG2DRD2DRD4DRD3 | |
| SCHEMBL11932443 | 0.83 | ARG1 (0.51) | ARG1ARG2DRD2HTR1AHTR2A | |
| SCHEMBL10006286 | 0.81 | MAPT (0.46) | ARG1ARG2DRD2DRD4DRD3 | |
| SCHEMBL17494183 | 0.76 | ARG1 (0.57) | ARG1ARG2 | |
| SCHEMBL18079438 | 0.75 | ARG1 (0.56) | ARG1ARG2 | |
| SCHEMBL10006138 | 0.74 | ARG1 (0.52) | ARG1ARG2 | |
| SCHEMBL10006564 | 0.74 | ARG1 (0.68) | ARG1ARG2CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447122-B2 | Arginase inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2016-09-20 | — | — | US | disclosed |