Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.53 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821095 | 0.87 | MAPT (0.62) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL17465580 | 0.87 | ALOX5 (0.74) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL15303659 | 0.85 | MAPT (0.71) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1820766 | 0.85 | CSNK2A1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12297485 | 0.84 | MAPT (0.55) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12297779 | 0.82 | MAPT (0.78) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1822119 | 0.82 | MAPT (0.78) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12297873 | 0.80 | ALOX5 (0.71) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL15303806 | 0.80 | MAPT (0.61) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12297472 | 0.80 | MAPT (0.61) | MAPTNPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447058-B2 | Substituted 1,3-thiazoles as heat shock transcription factor 1 activators | DUKE UNIVERSITY (US) | 2016-09-20 | — | — | US | disclosed |