Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 6/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804984 | 0.92 | TNNI3K (0.62) | BRAFTNNI3KSRCENPP1EGFR | |
| SCHEMBL1807327 | 0.82 | ENPP1 (0.57) | BRAFTNNI3KSRCENPP1EGFR | |
| SCHEMBL6912956 | 0.78 | BRAF (0.61) | BRAFTNNI3KSRCEGFRALDH1A1 | |
| SCHEMBL1808469 | 0.75 | BRAF (0.61) | BRAFTNNI3KENPP1EGFRKDR | |
| SCHEMBL6910970 | 0.72 | BRAF (0.72) | BRAFTNNI3KSRCEGFR | |
| Trifluoroacetic Acid SCHEMBL12003611 | 0.72 | BRAF (0.59) | BRAFTNNI3KSRCEGFRMKNK2 | |
| SCHEMBL6911924 | 0.72 | TNNI3K (0.73) | BRAFTNNI3KSRCEGFRMKNK2 | |
| Hydrochloric Acid SCHEMBL12004112 | 0.71 | BRAF (0.71) | BRAFTNNI3KSRCEGFR | |
| SCHEMBL6911594 | 0.71 | TNNI3K (0.81) | BRAFTNNI3KSRC | |
| SCHEMBL1809500 | 0.71 | BRAF (0.53) | BRAFTNNI3KSRCEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | claimed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | claimed |
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |