Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | RET | P07949 | 9/20 | 0.53 |
| ▸ | KIF5B | P33176 | 7/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | FLT1 | P17948 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808469 | 0.91 | BRAF (0.61) | ENPP1KDRRETKIF5BEGFR | |
| SCHEMBL1807986 | 0.82 | BRAF (0.52) | ENPP1KDREGFRBRAFTNNI3K | |
| SCHEMBL5652266 | 0.78 | EGFR (0.63) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL6911482 | 0.76 | KDR (0.60) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL1804984 | 0.75 | TNNI3K (0.62) | ENPP1EGFRBRAFTNNI3KSRC | |
| Hydrochloric Acid SCHEMBL12003797 | 0.75 | EGFR (0.60) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL1806890 | 0.73 | BRAF (0.59) | ENPP1KDRRETKIF5BEGFR | |
| SCHEMBL23762278 | 0.73 | ENPP1 (1.00) | ENPP1EGFR | |
| SCHEMBL12227578 | 0.71 | RET (0.70) | KDRRETKIF5BEGFRFLT1 | |
| SCHEMBL5864588 | 0.71 | EGFR (0.67) | KDRRETKIF5BEGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | claimed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | claimed |
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |