Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 16/20 | 0.59 |
| ▸ | SMARCA4 | P51532 | 16/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 16/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 10/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095334 | 0.82 | IDO1 (0.51) | SMARCA2SMARCA4ALDH1A1MAPT | |
| SCHEMBL22802813 | 0.75 | PBRM1 (0.72) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL18038695 | 0.74 | PBRM1 (1.00) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL21673521 | 0.74 | PBRM1 (0.66) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL18080927 | 0.74 | SMARCA2 (1.00) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL18038858 | 0.73 | SMARCA2 (0.60) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL2064569 | 0.73 | MAPT (0.49) | ALDH1A1MAPT | |
| SCHEMBL25349014 | 0.72 | PBRM1 (0.82) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL31396251 | 0.71 | PBRM1 (0.66) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL31396186 | 0.71 | PBRM1 (0.65) | SMARCA2SMARCA4PBRM1NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-10308614-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308614-B2 | Therapeutic compounds and uses thereof | SMARCC1, SMARCC2, SMARCA4 | SMARCA2 10/4885SMARCA4 3/4885PBRM1 11/4885 |
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | SMARCA2 10/4885SMARCA4 3/4885PBRM1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.