Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.64 |
| ▸ | CES1 | P23141 | 8/20 | 0.50 |
| ▸ | CES2 | O00748 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL10612029 | 0.87 | CA2 (0.48) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL3321929 | 0.84 | CA2 (0.89) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL348475 | 0.83 | CA2 (0.77) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL3488932 | 0.82 | CA2 (0.76) | CA2CA4CES1CES2CYP3A4 | |
| Benzoic Acid SCHEMBL11789341 | 0.82 | CA2 (0.94) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL28868137 | 0.81 | CA2 (0.74) | CA2CA4CES1CES2MAPT | |
| Benzoic Acid SCHEMBL11806242 | 0.81 | CA2 (0.67) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL11904021 | 0.81 | CA2 (0.74) | CA2CA4CES1CES2KDM4E | |
| Benzoic Acid SCHEMBL11740323 | 0.80 | CA2 (0.80) | CA2CA4CES1CES2CYP3A4 | |
| Benzoic Acid SCHEMBL28337190 | 0.80 | CA2 (0.80) | CA2CA4CES1CES2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233247-A4 | METHOD FOR WASTEWATER TREATMENT. | US ENVIRONMENT RESOURCES (US) | 1988-12-12 | — | — | EP | claimed |
| EP-0233247-A1 | METHOD FOR WASTEWATER TREATMENT | UNITED STATES ENVIRONMENTAL RESOURCES CORPORATION (US) | 1987-08-26 | — | — | EP | claimed |
| WO-1987000516-A1 | METHOD FOR WASTEWATER TREATMENT | UNITED STATES ENVIRONMENTAL RESOURCES CORPORATION (US) | 1987-01-29 | — | — | WO | claimed |
| US-4615807-A | QUATERNARY AMMONIUM SALTS AND ORGANOTIN MIXTURE TO DISINFECT | UNITED STATES ENVIRONMENTAL RESOURCES, CORP. (US) | 1986-10-07 | — | — | US | claimed |
| EP-0000879-B1 | PROCESS FOR THE PREPARATION OF AROMATIC CARBONIC ACID ESTERS | BAYER AG (DE) | 1980-08-20 | — | — | EP | claimed |
| EP-2711353-B1 | Process for the continuous manufacture of aryl alkyl carbonate and diaryl carbonate using vapor recompression | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2018-10-31 | — | — | EP | disclosed |
| EP-2970096-B1 | PROCESS FOR PURIFICATION OF DIPHENYL CARBONATE FOR THE MANUFACTURING OF HIGH QUALITY POLYCARBONATE | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2018-08-08 | — | — | EP | disclosed |
| EP-2816068-B1 | Process for the manufacture of polycarbonate compositions | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2017-12-27 | — | — | EP | disclosed |
| US-9765012-B2 | Method for producing diaryl carbonate | COVESTRO DEUTSCHLAND AG (DE) | 2017-09-19 | — | — | US | disclosed |
| US-9732028-B2 | Process for purification of diphenyl carbonate for the manufacturing of high quality polycarbonate | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-08-15 | — | — | US | disclosed |
| EP-2935197-B1 | METHOD FOR MANUFACTURING DIARYL CARBONATE | COVESTRO DEUTSCHLAND AG (DE) | 2017-07-12 | — | — | EP | disclosed |
| EP-2778186-B1 | Production of a polycarbonate with limited metal residuals | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2017-07-12 | — | — | EP | disclosed |
| EP-0608710-A1 | Process for the continuous preparation of aryle carbonates | BAYER AG (DE) | 1994-08-03 | — | — | EP | disclosed |
| US-5334742-A | Thermodynamic transesterification in presence of catalysts | BAYER AKTIENGESELLSCHAFT (DE) | 1994-08-02 | — | — | US | disclosed |
| EP-0582930-A2 | Process for the preparation of diarylcarbonates | BAYER AG (DE) | 1994-02-16 | — | — | EP | disclosed |
| EP-0582931-A2 | Process for the continuous preparation of diarylcarbonates from dialkylcarbonates | BAYER AG (DE) | 1994-02-16 | — | — | EP | disclosed |
| EP-0572870-A1 | Process for the production of organic carbonates with at least one aromatic ester group | BAYER AG (DE) | 1993-12-08 | — | — | EP | disclosed |
| US-4615807-A | QUATERNARY AMMONIUM SALTS AND ORGANOTIN MIXTURE TO DISINFECT | UNITED STATES ENVIRONMENTAL RESOURCES, CORP. (US) | 1986-10-07 | — | — | US | disclosed |
| US-4252737-A | Process for the production of aromatic carbonic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-24 | — | — | US | disclosed |
| EP-0000879-B1 | PROCESS FOR THE PREPARATION OF AROMATIC CARBONIC ACID ESTERS | BAYER AG (DE) | 1980-08-20 | — | — | EP | disclosed |