Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.37 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12393 | 0.83 | LMNA (0.46) | MEN1KMT2AKDM4ENPSR1POLB | |
| SCHEMBL12449661 | 0.83 | LMNA (0.46) | MEN1KMT2AKDM4ENPSR1POLB | |
| SCHEMBL12626 | 0.77 | NPC1 (0.44) | KDM4EL3MBTL1RAB9ABMP1LMNA | |
| SCHEMBL16400418 | 0.71 | BIRC2 (0.36) | WNT1GSK3BDYRK1A | |
| SCHEMBL21370068 | 0.71 | OGA (0.54) | MEN1KMT2AKDM4EPOLBLMNA | |
| SCHEMBL13036994 | 0.70 | GRIN2D (0.47) | NPSR1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL19851053 | 0.69 | KAT2B (0.48) | MEN1KMT2AKDM4ENPSR1POLB | |
| SCHEMBL16364797 | 0.69 | OPRL1 (0.39) | MEN1KMT2AKDM4EPOLBL3MBTL1 | |
| SCHEMBL16364796 | 0.69 | KDM4E (0.38) | MEN1KMT2AKDM4EPOLBL3MBTL1 | |
| SCHEMBL15219278 | 0.68 | CXCR4 (0.40) | MEN1KMT2ALMNAALDH1A1WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |