Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.76 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.47 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180999 | 0.89 | DGAT1 (0.77) | DGAT1SOAT1SOAT2 | |
| SCHEMBL13664060 | 0.89 | DGAT1 (0.77) | DGAT1SOAT1SOAT2 | |
| SCHEMBL14617022 | 0.89 | DGAT1 (0.77) | DGAT1SOAT1SOAT2 | |
| SCHEMBL180809 | 0.89 | DGAT1 (0.82) | DGAT1SOAT1 | |
| SCHEMBL14617045 | 0.89 | DGAT1 (0.82) | DGAT1SOAT1 | |
| SCHEMBL15445225 | 0.89 | DGAT1 (0.82) | DGAT1SOAT1 | |
| SCHEMBL13664086 | 0.89 | DGAT1 (0.82) | DGAT1SOAT1 | |
| SCHEMBL31326545 | 0.89 | DGAT1 (0.82) | DGAT1SOAT1 | |
| SCHEMBL181168 | 0.88 | DGAT1 (0.81) | DGAT1SOAT1 | |
| Pradigastat SCHEMBL29358725 | 0.86 | DGAT1 (1.00) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301923-B1 | PYRIDINE DERIVATIVES AS DGAT INHIBITORS | NOVARTIS AG (CH) | 2016-06-08 | — | — | EP | disclosed |
| EP-2418202-B1 | (4-[4-[5-(substituted amino)-pyridin-2-yl]phenyl]-cyclohexyl)-acetic acid derivatives as DGAT inhibitors | NOVARTIS AG (CH) | 2014-01-29 | — | — | EP | disclosed |
| CN-101415683-B | Novel compounds | NOVARTIS AG | 2013-07-17 | — | — | CN | disclosed |
| EP-2418202-A1 | New compounds | Novartis AG (CH) | 2012-02-15 | — | — | EP | disclosed |
| EP-2402319-A1 | DGAT Inhibitors | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402320-A1 | Anorectic agents | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402318-A1 | DGAT inhibitors | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| EP-2402317-A1 | DGAT inhibitor | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| EP-2301923-A1 | New compounds | Novartis AG (CH) | 2011-03-30 | — | — | EP | disclosed |
| CN-101415683-A | Novel compounds | NOVARTIS AG (CH) | 2009-04-22 | — | — | CN | disclosed |