Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 2/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | LPO | P22079 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18083997 | 0.88 | KMT2A (0.39) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL15765005 | 0.87 | CA12 (0.44) | KDM4ECA12CA1CA2CA7 | |
| SCHEMBL18106171 | 0.86 | MLYCD (0.38) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL18083999 | 0.86 | KMT2A (0.45) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL15758840 | 0.83 | SMN1; SMN2 (0.39) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15758042 | 0.83 | SMN1; SMN2 (0.39) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19937735 | 0.80 | SMN1; SMN2 (0.34) | KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2490683 | 0.80 | CA12 (0.41) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL2490681 | 0.80 | CA12 (0.41) | KMT2AMEN1KDM4ESMN1; SMN2CA12 | |
| SCHEMBL20663374 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10173999-B2 | Cyclic amine derivative and pharmaceutical use thereof | TORAY INDUSTRIES, INC. (JP) | 2019-01-08 | — | — | US | disclosed |
| US-20180065950-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2018-03-08 | — | — | US | disclosed |
| WO-2016136944-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 東レ株式会社 | 2016-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10173999-B2 | Cyclic amine derivative and pharmaceutical use thereof | OPRL1, PDE3A, TRPV1 | KMT2A 1160/4885MEN1 1113/4885KDM4E 1676/4885 |
| US-20180065950-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | OPRL1, PDE3A, TRPV1 | KMT2A 1160/4885MEN1 1113/4885KDM4E 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.