Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.37 |
| ▸ | GLP1R | P43220 | 8/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755924 | 0.94 | AKT1 (0.41) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL17488484 | 0.92 | AKT1 (0.40) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL11964062 | 0.92 | AKT1 (0.42) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL11964063 | 0.85 | SIRT2 (0.38) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL18480125 | 0.85 | AKT1 (0.39) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL277647 | 0.85 | SIRT2 (0.45) | AKT1SIRT2SIRT1SIRT3TPSAB1 | |
| SCHEMBL12389311 | 0.83 | SIRT2 (0.42) | AKT1SIRT2SIRT1SIRT3TPSAB1 | |
| SCHEMBL14542727 | 0.83 | AKT1 (0.36) | AKT1SIRT2SIRT1 | |
| SCHEMBL15146939 | 0.83 | SIRT2 (0.39) | SIRT2SIRT1GLP1RSIRT3TPSAB1 | |
| SCHEMBL12692598 | 0.82 | HDAC4 (0.41) | AKT1SIRT2SIRT1GLP1RSIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9433684-B2 | Conjugates of small-interfering nucleic acids | NEKTAR THERAPEUTICS (US) | 2016-09-06 | — | — | US | disclosed |