Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.35 |
| ▸ | GLP1R | P43220 | 7/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11964062 | 0.98 | AKT1 (0.42) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL18084214 | 0.94 | AKT1 (0.42) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL17488484 | 0.94 | AKT1 (0.40) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL11964063 | 0.91 | SIRT2 (0.38) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL14542727 | 0.89 | AKT1 (0.36) | AKT1SIRT2SIRT1 | |
| SCHEMBL18480125 | 0.89 | AKT1 (0.39) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL12389311 | 0.87 | SIRT2 (0.42) | AKT1SIRT2SIRT1SIRT3TPSAB1 | |
| SCHEMBL277647 | 0.87 | SIRT2 (0.45) | AKT1SIRT2SIRT1SIRT3TPSAB1 | |
| SCHEMBL12692598 | 0.83 | HDAC4 (0.41) | AKT1SIRT2SIRT1GLP1RSIRT3 | |
| SCHEMBL12721098 | 0.83 | SIRT6 (0.46) | AKT1SIRT2SIRT1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763995-B2 | Polymer conjugates of protegrin peptides | NEKTAR THERAPEUTICS (US) | 2017-09-19 | — | — | US | disclosed |
| US-9446139-B2 | Polymer-based compositions and conjugates of HIV entry inhibitors | NEKTAR THERAPEUTICS (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160175402-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2016-06-23 | — | — | US | disclosed |
| US-20160158311-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | NEKTAR THERAPEUTICS | 2016-06-09 | — | — | US | disclosed |
| US-20150038422-A1 | UNIT DOSAGE FORMS OF PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYMER-FACTOR VIII POLYPEPTIDE CONJUGATE | NEKTAR THERAPEUTICS | 2015-02-05 | — | — | US | disclosed |
| US-8889831-B2 | Unit dosage forms of pharmaceutical compositions comprising a polymer-factor VIII polypeptide conjugate | NEKTAR THERAPEUTICS (US) | 2014-11-18 | — | — | US | disclosed |
| US-8519102-B2 | Polymer Factor VIII moiety conjugates | NEKTAR THERAPEUTICS (US) | 2013-08-27 | — | — | US | disclosed |
| US-8449872-B2 | Polymer conjugates of nesiritide peptides | NEKTAR THERAPEUTICS (US) | 2013-05-28 | — | — | US | disclosed |
| US-8420068-B2 | Polymer-based compositions and conjugates of antimicrobial agents | NEKTAR THERAPEUTICS (US) | 2013-04-16 | — | — | US | disclosed |
| US-20130059360-A1 | POLYMER-BASED COMPOSITIONS AND CONJUGATES OF ANTIMICROBIAL AGENTS | NEKTAR THERAPEUTICS (US) | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038422-A1 | UNIT DOSAGE FORMS OF PHARMACEUTICAL COMPOSITIONS COMPRISING A POLYMER-FACTOR VIII POLYPEPTIDE CONJUGATE | F8, F13B, F13A1 | AKT1 3970/4885SIRT2 4418/4885SIRT1 4430/4885 |
| US-20160158311-A1 | POLYMER CONJUGATES OF PROTEGRIN PEPTIDES | PSMG3, PSMB11, UBQLN1 | AKT1 3349/4885SIRT2 3088/4885SIRT1 2971/4885 |
| US-20160175402-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | F8, F9, F13B | AKT1 3489/4885SIRT2 4157/4885SIRT1 4382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.