Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 11/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | NPY2R | P49146 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18088085 | 0.89 | TP53 (0.57) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL18088012 | 0.88 | TP53 (0.56) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL18087996 | 0.87 | TP53 (0.55) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL18088102 | 0.86 | TP53 (0.54) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL3114887 | 0.86 | KMT2A (0.67) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL18088077 | 0.85 | HDAC1 (0.64) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL20042056 | 0.83 | ABCG2 (0.53) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL24653613 | 0.81 | MAPT (0.54) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL19789212 | 0.81 | TP53 (0.52) | TP53MAPTKMT2AMEN1NPSR1 | |
| SCHEMBL28561652 | 0.80 | HDAC1 (0.52) | TP53MAPTKMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428705-B | Histone deacetylase inhibitor and preparation method and application thereof | 广东众生药业股份有限公司 | 2021-03-16 | — | — | CN | disclosed |
| US-20180098990-A1 | HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-12 | — | — | US | disclosed |
| US-20180098990-A1 | HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-04-12 | — | — | US | disclosed |
| WO-2016146074-A1 | HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | 广东众生药业股份有限公司 | 2016-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180098990-A1 | HISTONE DEACETYLASE INHIBITOR, AND PREPARATION METHOD AND USE THEREOF | HDAC1, HDAC5, HDAC9 | TP53 2767/4885MAPT 3211/4885KMT2A 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.