Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.57 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092046 | 0.88 | GABRA5 (0.46) | GABRA5ITGA5GABRA1 | |
| SCHEMBL18092075 | 0.88 | GABRA5 (0.56) | GABRA5ITGA5 | |
| SCHEMBL18092073 | 0.87 | GABRA5 (0.53) | GABRA5ITGA5GABRA1 | |
| SCHEMBL18092066 | 0.87 | GABRA5 (0.46) | GABRA5GABRA1 | |
| SCHEMBL18092026 | 0.86 | GABRA5 (0.57) | GABRA5ITGA5 | |
| SCHEMBL286350 | 0.86 | GABRA5 (0.61) | GABRA5ITGA5GABRA1 | |
| SCHEMBL18092054 | 0.85 | GABRA5 (0.55) | GABRA5ITGA5 | |
| SCHEMBL18092023 | 0.85 | GABRA5 (0.59) | GABRA5ITGA5GABRA1 | |
| SCHEMBL18092068 | 0.85 | GABRA5 (0.48) | GABRA5ITGA5 | |
| SCHEMBL18091970 | 0.82 | GABRA5 (0.48) | GABRA5ITGA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |