Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 12/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092033 | 0.91 | GABRA5 (0.43) | GABRA5ITGA5GLAALDH1A1POLB | |
| SCHEMBL18092019 | 0.91 | GABRA5 (0.45) | GABRA5ITGA5GLAALDH1A1POLB | |
| SCHEMBL18092051 | 0.90 | GABRA5 (0.53) | GABRA5ITGA5GLA | |
| SCHEMBL18092073 | 0.89 | GABRA5 (0.53) | GABRA5ITGA5 | |
| SCHEMBL18091969 | 0.89 | GABRA5 (0.51) | GABRA5ITGA5GLAALDH1A1 | |
| SCHEMBL18091996 | 0.87 | GABRA5 (0.46) | GABRA5ITGA5GLAALDH1A1POLB | |
| SCHEMBL18092029 | 0.87 | GABRA5 (0.52) | GABRA5ITGA5 | |
| SCHEMBL18092030 | 0.86 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL286063 | 0.84 | KDM4E (0.44) | GABRA5ITGA5LMNA | |
| SCHEMBL18092037 | 0.84 | GABRA5 (0.54) | GABRA5ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |