Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092012 | 0.92 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL286197 | 0.86 | GABRA5 (0.65) | GABRA5 | |
| SCHEMBL18092017 | 0.86 | GABRA5 (0.60) | GABRA5 | |
| SCHEMBL18092036 | 0.85 | GABRA5 (0.53) | GABRA5 | |
| SCHEMBL18091979 | 0.84 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL18092067 | 0.84 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL18091980 | 0.82 | GABRA5 (0.63) | GABRA5 | |
| SCHEMBL15252548 | 0.82 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL15252400 | 0.80 | GABRA5 (0.64) | GABRA5 | |
| SCHEMBL286305 | 0.79 | GABRA5 (0.58) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |