Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 17/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092058 | 0.87 | GABRA5 (0.40) | GABRA5 | |
| SCHEMBL286086 | 0.85 | GABRA5 (0.44) | GABRA5TGFBR1 | |
| SCHEMBL286085 | 0.85 | GABRA5 (0.44) | GABRA5TGFBR1 | |
| SCHEMBL18092061 | 0.85 | GABRA5 (0.38) | GABRA5 | |
| SCHEMBL18091975 | 0.85 | GABRA5 (0.44) | GABRA5TGFBR1 | |
| SCHEMBL18091961 | 0.84 | GABRA5 (0.38) | GABRA5 | |
| SCHEMBL18092042 | 0.83 | GABRA5 (0.41) | GABRA5 | |
| SCHEMBL285846 | 0.82 | GABRA5 (0.45) | GABRA5 | |
| SCHEMBL285847 | 0.82 | GABRA5 (0.45) | GABRA5 | |
| SCHEMBL18092079 | 0.82 | GABRA5 (0.42) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |