Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610117 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL1411269 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Hydrochloric Acid SCHEMBL1411730 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Bromide SCHEMBL1411311 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Sulfuric Acid SCHEMBL1411761 | 0.96 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Fumaric Acid SCHEMBL1411383 | 0.94 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Fumaric Acid SCHEMBL1411387 | 0.94 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Cadaverine Tartrate SCHEMBL1411136 | 0.93 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Alpha-Ketoglutaric Acid SCHEMBL1411504 | 0.91 | PDE4A (0.39) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL2265247 | 0.91 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962377-B2 | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | TAKEDA GMBH (DE) | 2018-05-08 | — | — | US | disclosed |
| US-20160279120-A1 | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | TAKEDA GMBH (DE) | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279120-A1 | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | PDE4A, PDE12, PDE4B | PDE4D 5/4885PDE4A 1/4885PDE4B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.