Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411269 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL18092835 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Hydrochloric Acid SCHEMBL1411730 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Bromide SCHEMBL1411311 | 0.99 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Sulfuric Acid SCHEMBL1411761 | 0.96 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Fumaric Acid SCHEMBL1411383 | 0.94 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Fumaric Acid SCHEMBL1411387 | 0.94 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Cadaverine Tartrate SCHEMBL1411136 | 0.93 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4CTP53 | |
| Alpha-Ketoglutaric Acid SCHEMBL1411504 | 0.91 | PDE4A (0.39) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL2265247 | 0.91 | PDE4A (0.41) | PDE4DPDE4APDE4BPDE4CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718668-B2 | phosphodiesterase inhibitor; drug for respiratory system disorders | NYCOMED GMBH (DE) | 2010-05-18 | — | — | US | disclosed |
| US-20080194587-A1 | phosphodiesterase inhibitor; drug for respiratory system disorders | NYCOMED GMBH (DE) | 2008-08-14 | — | — | US | disclosed |