Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 5/20 | 0.36 |
| ▸ | BMI1 | P35226 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.34 |
| ▸ | GALR1 | P47211 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18094405 | 0.87 | FLT3 (0.34) | GALR2GALR1SCN9AP2RX3TRPA1 | |
| SCHEMBL16747910 | 0.85 | GALR2 (0.35) | ROCK1GALR2BMI1MEN1ALDH1A1 | |
| SCHEMBL18094384 | 0.84 | ROCK1 (0.39) | ROCK1GALR2BMI1MEN1ALDH1A1 | |
| SCHEMBL18094404 | 0.79 | IDO1 (0.38) | MEN1KMT2AP2RX3TRPA1MAP3K5 | |
| SCHEMBL16740019 | 0.76 | ACP1 (0.41) | GALR2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16747979 | 0.76 | BMI1 (0.40) | ROCK1GALR2BMI1MEN1ALDH1A1 | |
| SCHEMBL16740351 | 0.76 | GALR2 (0.40) | ROCK1GALR2BMI1ALDH1A1MAPT | |
| SCHEMBL16747901 | 0.74 | P2RX3 (0.32) | P2RX3TRPA1 | |
| SCHEMBL16747840 | 0.73 | BMI1 (0.41) | ROCK1GALR2BMI1GALR1GSK3A | |
| SCHEMBL16740129 | 0.73 | SCN5A (0.39) | ROCK1GALR2BMI1GALR1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10584115-B2 | Substituted pyridine and pyrazine BMI-1 inhibitors | PTC THERAPEUTICS, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | ROCK1 2769/4885GALR2 4615/4885BMI1 1/4885 |
| US-10584115-B2 | Substituted pyridine and pyrazine BMI-1 inhibitors | BMI1, BAZ2A, BAZ2B | ROCK1 2769/4885GALR2 4615/4885BMI1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.