Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | NAT1 | P18440 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTP4A3 | O75365 | 5/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18095797 | 1.00 | PIM1 (0.60) | PIM1PDE4BGSK3BNAT1KMT2A | |
| SCHEMBL18102961 | 1.00 | PIM1 (0.60) | PIM1PDE4BGSK3BNAT1KMT2A | |
| SCHEMBL18102903 | 0.85 | PDE4B (0.73) | PDE4BGSK3BNAT1KMT2APTP4A3 | |
| SCHEMBL18102863 | 0.82 | PIM1 (0.51) | PIM1PDE4BGSK3BNAT1KMT2A | |
| SCHEMBL18102905 | 0.81 | GSK3B (0.75) | PIM1PDE4BGSK3BNAT1KMT2A | |
| SCHEMBL12892144 | 0.81 | GSK3B (0.75) | PIM1PDE4BGSK3BNAT1KMT2A | |
| SCHEMBL18102850 | 0.79 | MGAM (0.63) | PIM1PDE4BGSK3BNAT1PTP4A3 | |
| SCHEMBL18102859 | 0.78 | PTP4A3 (0.58) | PIM1GSK3BNAT1PTP4A3CRHBP | |
| SCHEMBL18103052 | 0.77 | PIM1 (0.74) | PIM1PDE4BGSK3BNAT1PTP4A3 | |
| SCHEMBL18102944 | 0.77 | PIM1 (0.74) | PIM1PDE4BGSK3BNAT1PTP4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-03-29 | — | — | US | disclosed |
| EP-3282846-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | University of Miami (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | PIM1 2196/4885PDE4B 3826/4885GSK3B 1070/4885 |
| US-20180086700-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | NOTCH1, CBFB, HES1 | PIM1 2196/4885PDE4B 3826/4885GSK3B 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.