Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19895449 | 0.88 | KDM1A (0.36) | KDM1ACACNA1HCACNA1GCACNA1IBACE1 | |
| SCHEMBL18096320 | 0.84 | BACE1 (0.40) | KDM1ABACE1CTSDCTSEMAPT | |
| SCHEMBL19913894 | 0.83 | KDM1A (0.43) | KDM1ACACNA1HBACE1CTSDCTSE | |
| SCHEMBL18096166 | 0.81 | BACE1 (0.38) | KDM1ABACE1CTSDCTSEMAPT | |
| SCHEMBL18096189 | 0.80 | BACE1 (0.40) | KDM1ACACNA1HBACE1CTSDCTSE | |
| SCHEMBL18096366 | 0.79 | TP53 (0.40) | KDM1ACACNA1HBACE1CTSDCTSE | |
| SCHEMBL18096182 | 0.78 | CACNA1G (0.42) | CACNA1HCACNA1GCACNA1IMAPTAADAT | |
| SCHEMBL18096370 | 0.73 | CACNA1G (0.34) | KDM1ACACNA1HCACNA1GCACNA1IAADAT | |
| SCHEMBL18096081 | 0.72 | SCD (0.44) | MAPTLMNATP53 | |
| SCHEMBL22660425 | 0.72 | CACNA1H (0.43) | KDM1ACACNA1HCACNA1GCACNA1IBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED | 2018-03-01 | — | — | US | disclosed |
| WO-2016154075-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | F2RL1, PARP12, TFPI2 | KDM1A 4316/4885CACNA1H 4745/4885CACNA1G 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.