Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18010243 | 0.92 | ADORA2B (0.55) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL5430644 | 0.88 | ADORA2B (0.48) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL5438969 | 0.88 | ADORA2B (0.47) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL16637157 | 0.87 | ADORA2B (0.71) | ADORA2BADORA2AADORA1 | |
| SCHEMBL16643996 | 0.86 | ADORA2B (0.70) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL18096860 | 0.86 | ADORA2B (0.44) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL16637406 | 0.84 | ADORA2B (0.49) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL16643807 | 0.83 | ADORA2B (0.55) | ADORA2BADORA2AADORA1MEN1KMT2A | |
| SCHEMBL16637750 | 0.78 | ADORA2B (0.73) | ADORA2BACACBACACA | |
| SCHEMBL21905384 | 0.77 | MEN1 (0.47) | ADORA2BADORA2AADORA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3274352-B1 | HETEROCYCLYLMETHYL-THIENOURACILE AS ANTAGONISTS OF THE ADENOSINE-A2B-RECEPTOR | Bayer Pharma AG (DE) | 2019-01-02 | — | — | EP | disclosed |
| EP-3274352-A1 | HETEROCYCLYLMETHYL-THIENOURACILE AS ANTAGONISTS OF THE ADENOSINE-A2B-RECEPTOR | Bayer Pharma Aktiengesellschaft (DE) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016150901-A1 | HETEROCYCLYLMETHYL-THIENOURACILE AS ANTAGONISTS OF THE ADENOSINE-A2B-RECEPTOR | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-09-29 | — | — | WO | disclosed |