Sugi Predict

Sugi Predict / Compounds / SCHEMBL1809753

SCHEMBL1809753

SCHEMBL1809753

COC(=O)c1ccc(-n2cnc3cc(C#N)ccc32)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 6/20 0.65
▸ GABRP O00591 2/20 0.51
▸ GABRD O14764 2/20 0.51
▸ GABRA1 P14867 2/20 0.51
▸ GABRB1 P18505 2/20 0.51
▸ GABRG2 P18507 2/20 0.51
▸ GABRB3 P28472 2/20 0.51
▸ GABRA5 P31644 2/20 0.51
▸ GABRA3 P34903 2/20 0.51
▸ GABRA2 P47869 2/20 0.51
▸ GABRB2 P47870 2/20 0.51
▸ GABRA4 P48169 2/20 0.51
▸ GABRE P78334 2/20 0.51
▸ GABRA6 Q16445 2/20 0.51
▸ GABRG1 Q8N1C3 2/20 0.51
▸ GABRG3 Q99928 2/20 0.51
▸ GABRQ Q9UN88 2/20 0.51
▸ GSK3B P49841 1/20 0.50
▸ ALDH1A1 P00352 2/20 0.47
▸ HPGD P15428 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25245906 0.93 FGFR1 (0.72) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL30440825 0.80 FGFR1 (0.71) FGFR1GABRPGABRDGABRA1GABRB1
SCHEMBL4502855 0.80 FGFR1 (0.79) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL25297465 0.80 FGFR1 (0.71) FGFR1GABRPGABRDGABRA1GABRB1
SCHEMBL23675303 0.79 FGFR1 (0.77) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL14065339 0.79 FGFR1 (0.77) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL144945 0.79 FGFR1 (0.77) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL2340072 0.79 FGFR1 (0.77) FGFR1GSK3BALDH1A1HPGDMAPT
SCHEMBL2570944 0.79 FGFR1 (1.00) FGFR1GSK3BHPGDMAPTSRC
SCHEMBL1812955 0.78 FGFR1 (1.00) FGFR1MAPTSRCRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7935719-B2 N-substituted-azacyclylamines as histamine-3 antagonists WYETH LLC (US) 2011-05-03 — — US disclosed
US-7935719-B2 N-substituted-azacyclylamines as histamine-3 antagonists WYETH LLC (US) 2011-05-03 — — US disclosed
EP-2074088-A2 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS Wyeth (US) 2009-07-01 — — EP disclosed
US-20080119458-A1 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS WYETH (US) 2008-05-22 — — US disclosed
US-20080119458-A1 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS WYETH (US) 2008-05-22 — — US disclosed
WO-2008045371-A2 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS WYETH (US) 2008-04-17 — — WO disclosed
WO-2008045371-A2 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS WYETH (US) 2008-04-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119458-A1 N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS HNMT, HRH4, HRH3 FGFR1 2424/4885GABRP 532/4885GABRD 559/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.