Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.57 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16739928 | 0.82 | CDK2 (0.40) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL18100935 | 0.81 | CDK2 (0.58) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL18100929 | 0.75 | CDK2 (0.52) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL21208238 | 0.75 | CDK2 (0.74) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL15741283 | 0.73 | ALDH1A1 (0.48) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL9611707 | 0.73 | ALDH1A1 (0.56) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL7964840 | 0.72 | CDK2 (1.00) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL15004600 | 0.72 | NPC1 (0.58) | CDK2CDK4ALDH1A1KDM4EGLA | |
| SCHEMBL21208156 | 0.71 | CDK2 (0.51) | CDK2CDK4CCNE1ALDH1A1KDM4E | |
| SCHEMBL21217027 | 0.71 | CDK2 (0.51) | CDK2CDK4CCNE1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | CDK2 1415/4885CDK4 1151/4885CCNE1 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.