Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.66 |
| ▸ | JAK1 | P23458 | 5/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18102152 | 0.94 | TYK2 (0.73) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL16712852 | 0.89 | TYK2 (0.71) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL18102144 | 0.84 | TYK2 (0.76) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL25536688 | 0.84 | TYK2 (0.88) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL18102136 | 0.83 | TYK2 (0.69) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL26462376 | 0.82 | TYK2 (0.73) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL16712874 | 0.82 | TYK2 (0.75) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL30636375 | 0.82 | TYK2 (0.75) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL25757318 | 0.81 | TYK2 (0.57) | TYK2JAK1CYP2C19JAK2 | |
| SCHEMBL16712856 | 0.81 | TYK2 (0.79) | TYK2JAK1CYP2C19JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9987266-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170209426-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-07-27 | — | — | US | disclosed |
| US-9663467-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160280649-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280649-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES | TYK2, IFNAR1, IFNG | TYK2 1/4885JAK1 16/4885CYP2C19 1991/4885 |
| US-20170209426-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNalpha RESPONSES | IFNAR1, TYK2, IFNG | TYK2 2/4885JAK1 16/4885CYP2C19 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.