SCHEMBL1810230

SCHEMBL1810230

Cc1cc(C(OS(C)(=O)=O)C(F)(F)F)cc(C)c1NC(=O)c1cccc(NC(=O)c2cccnc2Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
MEN1 O00255 1/20 0.48
ALDH1A1 P00352 2/20 0.42
MAPK10 P53779 1/20 0.42
MAPT P10636 2/20 0.41
MAPK1 P28482 1/20 0.41
BRAF P15056 7/20 0.40
CSF1R P07333 2/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
KCNK3 O14649 3/20 0.39
KCNK9 Q9NPC2 3/20 0.39
KIT P10721 1/20 0.39
KDR P35968 1/20 0.39
MAPK14 Q16539 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13497757 0.87 KMT2A (0.54) KMT2AMEN1ALDH1A1MAPTMAPK1
SCHEMBL1824389 0.86 KMT2A (0.53) KMT2AMEN1ALDH1A1MAPTMAPK1
SCHEMBL1812611 0.85 KMT2A (0.50) KMT2AMEN1ALDH1A1MAPK10MAPT
SCHEMBL1813971 0.83 KMT2A (0.46) KMT2AMEN1ALDH1A1MAPK10MAPT
SCHEMBL1813003 0.81 MEN1 (0.46) KMT2AMEN1ALDH1A1MAPK10MAPT
SCHEMBL1819735 0.81 KMT2A (0.55) KMT2AMEN1ALDH1A1MAPTMAPK1
SCHEMBL1824465 0.81 KMT2A (0.55) KMT2AMEN1ALDH1A1MAPTMAPK1
SCHEMBL1819496 0.78 MEN1 (0.44) KMT2AMEN1ALDH1A1MAPTBRAF
SCHEMBL1829076 0.78 MEN1 (0.52) KMT2AMEN1ALDH1A1MAPTBRAF
SCHEMBL1812890 0.77 MEN1 (0.48) KMT2AMEN1ALDH1A1MAPK10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110201603-A1 Novel Acylaminobenzamide Derivatives BAYER CROPSCIENCE AG (DE) 2011-08-18 US disclosed
EP-2318358-A2 ACYLAMINOBENZAMIDE DERIVATIVES Bayer CropScience AG (DE) 2011-05-11 EP disclosed
WO-2010015355-A2 NOVEL ACYLAMINOBENZAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2010-02-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110201603-A1 Novel Acylaminobenzamide Derivatives KCNB1, KCNA5, KCNA7 KMT2A 676/4885MEN1 3469/4885ALDH1A1 271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.