KCNA7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2585454	1.00	1/20
SCHEMBL29410610	1.00	1/20
SCHEMBL2585444	0.98	1/20
SCHEMBL2583446	0.95	1/20
SCHEMBL2585423	0.91	1/20
SCHEMBL2582557	0.89	1/20
SCHEMBL2576641	0.87	1/20
SCHEMBL2581526	0.79	1/20
SCHEMBL2576615	0.78	1/20
SCHEMBL2581117	0.78	1/20
SCHEMBL2583852	0.78	1/20
SCHEMBL2585968	0.78	1/20
SCHEMBL2801777	0.78	1/20
SCHEMBL26627232	0.78	1/20
SCHEMBL29386652	0.78	1/20
SCHEMBL2579395	0.77	1/20
SCHEMBL2580058	0.77	1/20
SCHEMBL2582554	0.77	1/20
SCHEMBL2586261	0.77	1/20
SCHEMBL2586446	0.77	1/20

Clinical trials — most relevant to KCNA7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart Disease	PHASE4	NOT_YET_RECRUITING
Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery	PHASE4	RECRUITING
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users	PHASE4	UNKNOWN
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study	PHASE3	COMPLETED
Safety and Tolerability of Lacosamide in Patients With Gain-of-function Nav1.7 Mutations Related Small Fiber Neuropathy	PHASE3	COMPLETED
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients	PHASE3	NOT_YET_RECRUITING
Mutation-specific Therapy for the Long QT Syndrome	PHASE2	COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients	PHASE2	COMPLETED
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss	PHASE2	COMPLETED
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy	PHASE1/PHASE2	RECRUITING
A First-in-Human SAD and MAD Study in Healthy Participants to Evaluate Oral YR011 Tablet	PHASE1	NOT_YET_RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK	PHASE1	COMPLETED
Peripheral KV7 Activation for Pain Relief	EARLY_PHASE1	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism	nan	COMPLETED
Qatar Cardiovascular Biorepository of AF Patients	nan	UNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy	nan	UNKNOWN
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
The Effects of the Anesthetic Drug Propofol on the Way the Heart Recovers Between Beats	nan	COMPLETED
The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats	nan	COMPLETED
Characteristics of Episodic Ataxia Syndrome	nan	COMPLETED
Sodium Channel Splicing in Obstructive Sleep Apnea (SOCS-OSA)	nan	COMPLETED
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)	nan	UNKNOWN
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a KCNA7 binder may also engage these)

Protein	Name	Similarity
Q17ST2	—	1.000	Q17ST2 →
A4K2P6	—	0.995	A4K2P6 →
A4K2M4	—	0.994	A4K2M4 →
A4K2Y2	—	0.992	A4K2Y2 →
A4K2T1	—	0.991	A4K2T1 →
A4K2X4	—	0.990	A4K2X4 →
O35173	—	0.989	O35173 →
A4K2R3	—	0.988	A4K2R3 →
A4K2V2	—	0.987	A4K2V2 →
P17659	—	0.987	P17659 →
A4K2W6	—	0.986	A4K2W6 →
O88758	—	0.986	O88758 →
P15388	—	0.985	P15388 →
A4K2N8	—	0.984	A4K2N8 →
P50638	—	0.983	P50638 →
A4K2S2	—	0.983	A4K2S2 →
KCNC1	Voltage-gated potassium channel KCNC1	0.983	landscape →
Q96KK3	—	0.983	Q96KK3 →
Q8TAE7	—	0.981	Q8TAE7 →
P25122	—	0.981	P25122 →
A4K2Q6	—	0.981	A4K2Q6 →
Q8TDN2	—	0.980	Q8TDN2 →
KCNA6	Potassium voltage-gated channel subfamily A member 6	0.980	landscape →
KCNA5	Potassium voltage-gated channel subfamily A member 5	0.979	landscape →
Q63734	—	0.979	Q63734 →
Q8R523	—	0.979	Q8R523 →
P19024	—	0.979	P19024 →
Q8BZN2	—	0.979	Q8BZN2 →
P16390	—	0.978	P16390 →
Q03721	—	0.977	Q03721 →