Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.38 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12318662 | 0.85 | TDP1 (0.51) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL11989021 | 0.84 | TDP1 (0.55) | TDP1GAAMEN1KMT2AMAOA | |
| SCHEMBL18100119 | 0.84 | TDP1 (0.42) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL15575825 | 0.82 | TDP1 (0.57) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL31672311 | 0.82 | TDP1 (0.62) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL887546 | 0.81 | TDP1 (0.65) | TDP1TSHRGAAMEN1KMT2A | |
| SCHEMBL7713907 | 0.81 | TDP1 (0.65) | TDP1TSHRGAAMEN1KMT2A | |
| SCHEMBL16883899 | 0.80 | TDP1 (0.46) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL9138923 | 0.77 | TSHR (0.46) | TDP1ALDH1A1TSHRMAPK1GAA | |
| SCHEMBL20000 | 0.77 | TSHR (1.00) | TDP1ALDH1A1TSHRMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683379-B2 | Polymers, hydrogels, and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-06-16 | — | — | US | disclosed |
| US-20160280827-A1 | POLYMERS, HYDROGELS, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683379-B2 | Polymers, hydrogels, and uses thereof | BOLA2; BOLA2B, PARG, BRAP | TDP1 480/4885ALDH1A1 2147/4885TSHR 4354/4885 |
| US-20160280827-A1 | POLYMERS, HYDROGELS, AND USES THEREOF | BOLA2; BOLA2B, PARG, BRAP | TDP1 480/4885ALDH1A1 2147/4885TSHR 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.