Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | NSD2 | O96028 | 1/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886396 | 0.93 | KMT2A (0.70) | KMT2AMEN1NSD2HSP90AA1APOBEC3G | |
| SCHEMBL6886400 | 0.93 | KMT2A (0.70) | KMT2AMEN1NSD2HSP90AA1APOBEC3G | |
| SCHEMBL12008471 | 0.91 | POLB (0.69) | KMT2AMEN1FFAR1POLBMAPT | |
| SCHEMBL12008468 | 0.86 | CTNNB1 (0.72) | KMT2AMEN1FFAR1POLBMAPT | |
| SCHEMBL18102937 | 0.86 | MEN1 (0.73) | KMT2AMEN1NSD2HSP90AA1APOBEC3G | |
| SCHEMBL18102872 | 0.85 | MEN1 (0.71) | KMT2AMEN1NSD2HSP90AA1APOBEC3G | |
| SCHEMBL12008566 | 0.84 | CISD1 (0.73) | KMT2AMEN1NSD2HSP90AA1APOBEC3G | |
| SCHEMBL15708889 | 0.83 | FFAR1 (0.92) | KMT2AMEN1FFAR1POLBMAPT | |
| SCHEMBL30919380 | 0.83 | FFAR1 (0.92) | KMT2AMEN1FFAR1POLBMAPT | |
| SCHEMBL15708888 | 0.83 | FFAR1 (0.92) | KMT2AMEN1FFAR1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |