Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | NSD2 | O96028 | 1/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.73 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.73 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.58 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18103010 | 0.89 | MEN1 (0.68) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL7250592 | 0.89 | PTPN12 (0.59) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL7250589 | 0.89 | PTPN12 (0.59) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL1448003 | 0.88 | MEN1 (0.58) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL6886400 | 0.88 | KMT2A (0.70) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL6886396 | 0.88 | KMT2A (0.70) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18102873 | 0.86 | KMT2A (0.67) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18095863 | 0.85 | CTNNB1 (0.65) | MEN1KMT2APOLB | |
| SCHEMBL18102989 | 0.85 | CTNNB1 (0.65) | MEN1KMT2APOLB | |
| SCHEMBL18095861 | 0.85 | CTNNB1 (0.65) | MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |