Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676717 | 0.89 | KMT2A (0.58) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL8781421 | 0.79 | HTT (0.65) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL4947647 | 0.79 | HTT (0.65) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18106966 | 0.78 | HDAC3 (0.66) | KMT2AMEN1ALDH1A1HTTKDM4E | |
| SCHEMBL6190463 | 0.78 | HTT (0.63) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL15134835 | 0.78 | HTT (0.72) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL7233482 | 0.77 | ALDH1A1 (0.54) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL10373273 | 0.77 | HTT (0.62) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL10245532 | 0.76 | HTT (0.65) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL19961339 | 0.75 | ALDH1A1 (0.67) | KMT2AMEN1HSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493862-B1 | IMIDAZOLE DERIVATIVES AS IDO INHIBITORS | NEWLINK GENETICS CORP (US) | 2016-10-05 | — | — | EP | disclosed |