Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246583 | 0.92 | LMNA (0.84) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL31292396 | 0.84 | KMT2A (0.89) | LMNAKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1806906 | 0.84 | LMNA (1.00) | LMNAKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9988878 | 0.83 | KMT2A (0.65) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL31292576 | 0.78 | KMT2A (0.59) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL1551107 | 0.76 | KMT2A (0.56) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL23534866 | 0.72 | KMT2A (0.51) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL26459091 | 0.71 | KMT2A (0.50) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL13040072 | 0.71 | LMNA (0.50) | LMNAKMT2AALDH1A1MAPTHTT | |
| SCHEMBL223549 | 0.71 | GAA (0.68) | LMNAALDH1A1HTTCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313407-B1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2016-10-05 | — | — | EP | disclosed |